Description

1-[2-[Bis(tert-Butyl)Phosphino]Phenyl]-3,5-Diphenyl-1H-Pyrazole is a specialized organophosphorus ligand, a critical component in modern catalytic chemistry. Its primary value lies in its ability to form highly active and selective metal complexes, particularly for cross-coupling reactions essential in fine chemical and pharmaceutical synthesis. This compound is a key material for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over catalytic processes.

Application

• Homogeneous Catalysis: As a privileged ligand for palladium, nickel, and other transition metals in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck, Negishi).
• Pharmaceutical Intermediate Synthesis: Enabling the efficient and selective construction of complex carbon-carbon and carbon-heteroatom bonds in API development.
• Agrochemical Research: Used in the catalytic synthesis of novel active ingredients and intermediates for crop protection products.
• Material Science: Facilitating catalytic processes in the development of organic electronic materials, polymers, and specialty chemicals.
• Asymmetric Synthesis: Potential use in designing chiral variants for enantioselective catalytic transformations.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic pathways in laboratory and pilot-scale settings.

Basic Information

Item	Details
Product Name	1-[2-[Bis(tert-Butyl)Phosphino]Phenyl]-3,5-Diphenyl-1H-Pyrazole
CAS No.	628333-86-8
Molecular Formula	C29H35N2P
Molecular Weight	442.58 g/mol
Synonyms	1-[2-[Bis(1,1-Dimethylethyl)Phosphino]Phenyl]-3,5-Diphenyl-1H-Pyrazole; 2-(Di-tert-butylphosphino)-1-(3,5-diphenyl-1H-pyrazol-1-yl)benzene; (2-(Di-tert-butylphosphino)phenyl)(3,5-diphenyl-1H-pyrazol-1-yl); JohnPhos-type Pyrazole Ligand; DTBP-Pyrazole Ligand; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of 1-[2-[Bis(tert-Butyl)Phosphino]Phenyl]-3,5-Diphenyl-1H-Pyrazole adheres to stringent internal quality standards to ensure batch-to-batch consistency and high ligand purity, which is critical for catalytic performance. Each lot is characterized by NMR (1H, 13C, 31P) and HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.