Description

3-Bromo-5-(Trifluoromethyl)Anisole is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions and as a precursor for liquid crystals and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated, fluorinated aromatic cores.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and other advanced organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Research: Employed in academic and industrial R&D for exploring new reaction methodologies and constructing complex molecular architectures.
• Fluorine Chemistry: A valuable starting material for further functionalization in fluorochemical research, leveraging the stable CF3 group.

Basic Information

Product Name	3-Bromo-5-(Trifluoromethyl)Anisole
CAS No.	627527-23-5
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	1-Bromo-3-methoxy-5-(trifluoromethyl)benzene; 3-Bromo-5-(trifluoromethoxy)benzene (common misnomer); 5-Bromo-1-methoxy-3-(trifluoromethyl)benzene; m-Bromo-m-trifluoromethylanisole; 3-Bromo-α,α,α-trifluoro-5-methoxytoluene; Benzene, 1-bromo-3-methoxy-5-(trifluoromethyl)-; Anisole, 3-bromo-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed and stored in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.