Description

2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block crucial for modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from the stability and reactivity of the pinacol boronate group.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors, where fluorinated units modify electronic properties.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling, facilitating the efficient and selective formation of biaryl and other complex organic structures.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and biomarkers for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical and CDMO (Contract Development and Manufacturing Organization) partners.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	627526-48-1
Molecular Formula	C₁₃H₁₅BF₄O₂
Molecular Weight	290.07 g/mol
Synonyms	2-Fluoro-3-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Fluoro-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [2-fluoro-3-(trifluoromethyl)phenyl]boronate; 2-Fluoro-α,α,α-trifluoro-m-tolylboronic acid pinacol ester; B-[2-Fluoro-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 627526-48-1; Boronic acid, B-[2-fluoro-3-(trifluoromethyl)phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.