Description

2-(3-(Difluoromethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality precursors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated and difluoromethylated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethyl and fluorophenyl motifs impart desirable biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics, via cross-coupling polymerization.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized to create fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(3-(Difluoromethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	627526-04-9
Molecular Formula	C13H16B1F3O2
Molecular Weight	272.08 g/mol
Synonyms	(3-(Difluoromethyl)-5-fluorophenyl)boronic acid pinacol ester; 5-Fluoro-3-(difluoromethyl)benzeneboronic acid pinacol ester; (5-Fluoro-3-(difluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [3-(difluoromethyl)-5-fluorophenyl]boronate; 3-Difluoromethyl-5-fluorophenylboronic acid pinacol ester; Boronic acid, B-[3-(difluoromethyl)-5-fluorophenyl]-, 1,1,1,1-tetramethyl-1,3-propanediyl ester; 627526-04-9 (CAS)
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-(Difluoromethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and other relevant analytical techniques. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.