Description

3-(Trifluoromethyl)-5-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is essential as a key building block in modern cross-coupling reactions, enabling the precise construction of complex fluorinated aromatic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules. The CAS number for this compound is provided in the table below.

Application

This versatile boronic ester is a critical intermediate in advanced organic synthesis, with key applications including:

• Pharmaceutical Intermediates: A key building block in Suzuki-Miyaura cross-couplings for creating novel drug candidates, particularly those containing trifluoromethyl and fluorine substituents for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the specific fluorinated aromatic motif is required for activity.
• Materials Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where precise control over aromatic structure is critical.
• Chemical Biology & Diagnostics: Serves as a precursor for fluorinated probes, tags, and molecular imaging agents.
• Process Chemistry & Scale-up: Provides a stable, storable alternative to the corresponding boronic acid for large-scale manufacturing processes.

Basic Information

Item	Details
Product Name	3-(Trifluoromethyl)-5-Fluorophenylboronic Acid Pinacol Ester
CAS No.	627525-87-5
Molecular Formula	C₁₃H₁₅BF₄O₂
Molecular Weight	290.07 g/mol
Synonyms	5-Fluoro-3-(trifluoromethyl)benzeneboronic acid pinacol ester; [5-Fluoro-3-(trifluoromethyl)phenyl]boronic acid pinacol ester; 3-Fluoro-5-(trifluoromethyl)phenylboronic acid pinacol ester; 5-Fluoro-α,α,α-trifluoro-m-tolueneboronic acid pinacol ester; Pinacol [3-fluoro-5-(trifluoromethyl)phenyl]boronate; (5-Fluoro-3-trifluoromethylphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-5-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC/NMR). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.