Description

4-Chloro-3-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to construct complex biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted biphenyl structures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated biaryl motifs.
• Material Science: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Research: Employed in academic and industrial R&D for method development and the construction of complex molecular libraries for screening.
• Ligand & Catalyst Preparation: Useful in the synthesis of specialized ligands and organometallic catalysts.

Basic Information

Product Name	4-Chloro-3-Fluorophenylboronic Acid Pinacol Ester
CAS No.	627525-83-1
Molecular Formula	C₁₂H₁₅BClFO₂
Molecular Weight	255.51 g/mol
Synonyms	4-Chloro-3-fluorobenzeneboronic acid pinacol ester; (4-Chloro-3-fluorophenyl)boronic acid pinacol ester; 2-(4-Chloro-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3-fluorophenyl-Bpin; 4-Chloro-3-fluoro-1-boronic acid pinacol ester; Pinacol (4-chloro-3-fluorophenyl)boronate; CAS 627525-83-1
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.