Description

Proline, 1-(Aminomethyl)- (9Ci) is a specialized proline derivative characterized by an additional aminomethyl functional group. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for creating complex molecules with specific stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in academic settings for studying peptide mimetics and bio-conjugates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for protease inhibitors and other bioactive peptides.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is critical for activity.
• Peptidomimetics Research: Acts as a constrained scaffold in designing peptide analogs with enhanced metabolic stability and bioavailability for therapeutic applications.
• Bioconjugation Chemistry: The reactive aminomethyl group facilitates its use in linking peptides or other molecules to carriers, labels, or solid supports.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes to study enzyme mechanisms or protein-protein interactions.

Basic Information

Product Name	Proline, 1-(Aminomethyl)- (9Ci)
CAS No.	627459-05-6
Molecular Formula	C6H12N2O2
Molecular Weight	144.17 g/mol
Synonyms	1-(Aminomethyl)proline; (S)-1-(Aminomethyl)pyrrolidine-2-carboxylic acid; 2-Pyrrolidinecarboxylic acid, 1-(aminomethyl)-, (S)-; 1-Aminomethyl-L-proline; L-Proline, 1-(aminomethyl)-; Aminomethylproline; (2S)-1-(Aminomethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Proline, 1-(Aminomethyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.