Description

4-Acetamido-3-Fluorophenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functional groups, enabling its use as a key intermediate in the synthesis of complex pharmaceutical compounds and advanced materials. This high-purity intermediate is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing novel molecules via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine and acetamido groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Ligand Synthesis for Catalysis: Used to create sophisticated bidentate or tridentate ligands for transition metal catalysts in asymmetric synthesis.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse compound libraries in medicinal chemistry for hit identification and lead optimization.

Basic Information

Product Name	4-Acetamido-3-Fluorophenylboronic Acid
CAS No.	626251-12-5
Molecular Formula	C8H9BFNO3
Molecular Weight	196.97 g/mol
Synonyms	3-Fluoro-4-acetamidophenylboronic Acid; N-[3-Fluoro-4-(dihydroxyboranyl)phenyl]acetamide; 4-Acetylamino-3-fluorobenzeneboronic Acid; 4-Acetamido-3-fluorobenzeneboronic Acid; B-(4-Acetamido-3-fluorophenyl)boronic Acid; (4-Acetamido-3-fluorophenyl)boronic Acid; 3-Fluoro-4-acetylaminophenylboronic Acid; 626251-12-5
EINECS	Contact for details

Quality Control

Our 4-Acetamido-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in common organic solvents (e.g., DMF, DMSO, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.