Description

n-Fmoc-6-Phenylmethoxy-L-Norleucine is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing therapeutic peptides and investigating protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the sequential assembly of custom peptide sequences.
• Peptidomimetic Drug Discovery: Used to incorporate non-natural side chains, enhancing metabolic stability and binding affinity of lead compounds.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides used in biochemical assays and diagnostic tools.
• Academic and Industrial Research: Essential for studying structure-activity relationships (SAR) in medicinal chemistry projects.
• API Intermediate Synthesis: Employed in the research-scale synthesis of potential Active Pharmaceutical Ingredients (APIs) with peptide backbones.

Basic Information

Product Name	n-Fmoc-6-Phenylmethoxy-L-Norleucine
CAS No.	625845-42-3
Molecular Formula	C₂₉H₃₁NO₅
Molecular Weight	473.56 g/mol
Synonyms	Fmoc-6-(Benzyloxy)-L-norleucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(benzyloxy)hexanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-(phenylmethoxy)-L-norleucine; Fmoc-Lys(Bzl)-OH (common misnomer for 6-substituted norleucine); Fmoc-6-O-Benzyl-L-homoSer (analogous naming); N-α-Fmoc-6-O-benzyl-L-homoserine; Protected L-Norleucine derivative; Fmoc-6-(OBzl)-L-Nle-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-6-Phenylmethoxy-L-Norleucine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.