Description

(3S)-3-Aminoazepane-1-Carboxylic Acid tert-Butyl Ester CAS NO 625471-04-7 is a high-purity, chiral azepane derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined aminoazepane scaffold essential for constructing complex molecules with high biological relevance. This intermediate is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel therapeutic agents, particularly in areas like protease inhibitors and central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Protease Inhibitor Development: Used in constructing the core structures of inhibitors targeting various proteases.
• Peptidomimetics & Constrained Peptides: Incorporates the seven-membered azepane ring to confer conformational rigidity and metabolic stability to peptide-based compounds.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce chiral complexity into target molecules.
• CNS Drug Discovery: Applied in the research of compounds designed to cross the blood-brain barrier.

Basic Information

Product Name	(3S)-3-Aminoazepane-1-Carboxylic Acid tert-Butyl Ester
CAS No.	625471-04-7
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	(3S)-3-Aminoazepane-1-carboxylic acid tert-butyl ester; tert-Butyl (3S)-3-aminoazepane-1-carboxylate; (S)-tert-Butyl 3-aminoazepane-1-carboxylate; (3S)-3-Amino-1-(tert-butoxycarbonyl)azepane; 1-Boc-(3S)-3-aminoazepane; Azepane-1-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3S)-; (S)-3-Aminoazepane-1-carboxylic acid tert-butyl ester; (S)-1-Boc-3-aminoazepane
EINECS	Contact for details

Quality Control

Our (3S)-3-Aminoazepane-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.