Description

(R)-1-Cbz-2-Cyano-Pyrrolidine CAS NO 620601-77-6 is a high-value, chiral pyrrolidine derivative widely used as a critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is particularly sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other bioactive molecules requiring a defined (R)-pyrrolidine scaffold.
• Asymmetric Catalysis Ligand Precursor: Used in the development of novel chiral ligands and organocatalysts for stereoselective transformations.
• Agrochemical Research: Serves as a building block for creating novel pesticides and herbicides with specific chiral activity.
• Peptidomimetics Development: Integral for constructing proline analogs and constrained peptide structures in medicinal chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, enantiomerically pure intermediates.

Basic Information

Product Name	(R)-1-Cbz-2-Cyano-Pyrrolidine
CAS No.	620601-77-6
Molecular Formula	C13H14N2O2
Molecular Weight	230.26 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-2-pyrrolidinecarbonitrile; (R)-1-Carbobenzoxy-2-cyanopyrrolidine; (R)-N-Cbz-2-Cyanopyrrolidine; (R)-2-Cyano-1-(phenylmethoxy)carbonylpyrrolidine; (R)-1-(Benzyloxycarbonyl)-2-cyanopyrrolidine; (R)-N-Benzyloxycarbonyl-2-cyanopyrrolidine; (2R)-1-[(Phenylmethoxy)carbonyl]-2-pyrrolidinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of (R)-1-Cbz-2-Cyano-Pyrrolidine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥97% by HPLC), enantiomeric excess (ee), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.