Description

Dota-Noc, Dota-[Nal3]-Octreotide is a synthetic peptide derivative, specifically a modified octreotide analogue designed for targeted diagnostic and therapeutic applications. This compound is engineered for high-affinity binding to somatostatin receptors, making it a critical component in the development of advanced radiopharmaceuticals. It serves as a key precursor for radiolabeling with isotopes like Gallium-68 or Lutetium-177, primarily for researchers and manufacturers in the fields of nuclear medicine, oncology, and molecular imaging.

Application

• Radiopharmaceutical Precursor: Primary use as a chelator-peptide conjugate for labeling with diagnostic (e.g., Ga-68) or therapeutic (e.g., Lu-177) radionuclides.
• PET/SPECT Imaging Agent Development: Synthesis of targeted probes for the non-invasive detection and staging of neuroendocrine tumors (NETs) and other somatostatin receptor-positive cancers.
• Targeted Radionuclide Therapy (TRT): Development of peptide receptor radionuclide therapy (PRRT) agents for cancer treatment.
• Research & Development: Tool compound for studying somatostatin receptor biology, pharmacokinetics, and new targeting strategies in academic and pharmaceutical R&D.
• Theragnostic Pair Development: Enabling the creation of matched diagnostic and therapeutic agent pairs for personalized medicine approaches.
• GMP-Grade Manufacturing: Sourcing for cGMP-compliant production of clinical-grade radiopharmaceuticals.

Basic Information

Product Name	Dota-Noc, Dota-[Nal3]-Octreotide
CAS No.	619300-53-7
Molecular Formula	C71H100N18O21S2
Molecular Weight	1581.8 g/mol
Synonyms	DOTA-[Nal3]-Octreotide; DOTA-NOC; DOTA-1-Nal3-Octreotide; DOTA-Nal3-OCT; (DOTA0,1-Nal3)octreotide; Ga-68 DOTA-NOC precursor; DOTA-conjugated [1-Nal3]-Octreotide; DOTA-1-Naphthylalanine3-Octreotide
EINECS	Contact for details

Quality Control

Our Dota-[Nal3]-Octreotide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry (MS) for confirmation, and rigorous checks for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment. The product can be supplied under GMP-grade conditions for clinical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 15.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.