Description

Voriconazole n-Oxide is a key pharmaceutical intermediate and metabolite of the antifungal agent Voriconazole. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on antifungal drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of advanced antifungal agents and related compounds.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for quantifying Voriconazole and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, bioavailability, and excretion profiles of Voriconazole.
• Analytical Method Development: Serves as a high-purity standard for validating HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Impurity Profiling: Used to identify, characterize, and control process-related impurities in Voriconazole API manufacturing.
• Academic and Clinical Research: Supports investigative studies into antifungal resistance mechanisms and therapeutic drug monitoring (TDM).

Basic Information

Product Name	Voriconazole n-Oxide
CAS No.	618109-05-0
Molecular Formula	C16H14F3N5O2
Molecular Weight	365.31 g/mol
Synonyms	Voriconazole N-Oxide; UK-115,794; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol N-Oxide; Voriconazole Metabolite; Voriconazole Oxide; Voriconazole N-Oxide Metabolite; 4-Pyrimidinol, 5-fluoro-4-[2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1-(1-hydroxy-1-methylethyl)butyl]-, 1-oxide
EINECS	Contact for details

Quality Control

Our Voriconazole n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.