Description

1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and fluoro substituents on the phenyl ring and a trifluoroacetyl group, makes it a versatile and valuable precursor for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a critical intermediate for the development of new active ingredients, particularly where the introduction of fluorine atoms is desired to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to enhanced efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl structures.
• Fluorine Chemistry Studies: Employed in academic and industrial R&D to study the effects of multiple fluorine atoms on reaction pathways and molecular properties.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services to produce tailored compounds for specific client research programs.

Basic Information

Product Name	1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One
CAS No.	617706-15-7
Molecular Formula	C8H3BrF4O
Molecular Weight	270.99 g/mol
Synonyms	5'-Bromo-2'-fluoro-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(5-bromo-2-fluorophenyl)ethanone; 1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanone; 5-Bromo-2-fluoro-α,α,α-trifluoroacetophenone; 2-Fluoro-5-bromo-α,α,α-trifluoroacetophenone; (5-Bromo-2-fluorophenyl)(trifluoromethyl)methanone; 617706-15-7 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.