Description

(R)-A-(Fmoc-Amino)-3-Hydroxy-Benzeneacetic Acid CAS NO 615553-60-1 is a high-purity, non-natural amino acid derivative featuring a chiral center and a base-labile Fmoc protecting group. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise introduction of a phenolic hydroxyl moiety. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral amino acid component for the automated synthesis of bioactive peptides.
• Pharmaceutical Intermediate: For the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Incorporation into non-peptide scaffolds to enhance metabolic stability and bioavailability of drug candidates.
• Bioconjugation: Utilized for coupling peptides to other molecules, surfaces, or carriers via its reactive carboxylic acid and phenolic groups.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular processes.
• Material Science: Building block for creating functionalized polymers and hydrogels with specific biological activity.

Basic Information

Product Name	(R)-A-(Fmoc-Amino)-3-Hydroxy-Benzeneacetic Acid
CAS No.	615553-60-1
Molecular Formula	C23H19NO5
Molecular Weight	389.40 g/mol
Synonyms	(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-hydroxyphenyl)acetic acid; Fmoc-3-hydroxy-D-phenylglycine; Fmoc-D-3-hydroxyphenylglycine; (R)-2-(Fmoc-amino)-2-(3-hydroxyphenyl)acetic acid; (R)-N-Fmoc-3-hydroxyphenylglycine; D-3-Hydroxyphenylglycine, N-Fmoc derivative; Fmoc-D-3-HPA; (R)-α-(Fmoc-amino)-3-hydroxybenzenacetic acid
EINECS	Contact for details

Quality Control

Our (R)-A-(Fmoc-Amino)-3-Hydroxy-Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.