Description

Formoterol o-β-D-Glucuronide is a major, pharmacologically inactive metabolite of the long-acting β2-adrenergic receptor agonist formoterol, formed via glucuronidation. This reference standard is critical for analytical and bioanalytical research, enabling the precise quantification of formoterol and its metabolic pathways. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies focused on drug metabolism, pharmacokinetic studies, and doping control analysis.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods, particularly HPLC and LC-MS/MS.
• Metabolite Identification & Quantification: Essential for in vitro and in vivo studies to identify, characterize, and quantify formoterol glucuronide metabolites in biological matrices like plasma and urine.
• Doping Control Analysis: Used by anti-doping laboratories as a key marker to detect and confirm the use of formoterol, a prohibited substance in athletic competitions under certain conditions.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating robust bioanalytical assays to support clinical trials and pharmacokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Fundamental for studying the absorption, distribution, metabolism, and excretion (ADME) profile of formoterol.
• Impurity Profiling: Used in the quality control of formoterol drug substances and products to identify and control potential glucuronide-related impurities.

Basic Information

Product Name	Formoterol o-β-D-Glucuronide
CAS No.	615551-59-2
Molecular Formula	C27H38N2O12
Molecular Weight	582.60 g/mol
Synonyms	Formoterol Glucuronide; Formoterol O-Glucuronide; (R*,R*)-(±)-2'-Hydroxy-5'-((RS)-1-hydroxy-2-((RS)-p-methoxy-α-methylphenethylamino)ethyl)formanilide o-β-D-Glucuronide; 2-Hydroxy-5-[(1RS)-1-hydroxy-2-{[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]formanilide β-D-Glucopyranosiduronic Acid; Formoterol Metabolite; BD 40A o-Glucuronide; Eformoterol Glucuronide; Arformoterol Glucuronide
EINECS	Contact for details

Quality Control

Our Formoterol o-β-D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.