Description

1-[(2R)-3-Hydroxy-2-Methyl-1-Oxopropyl]-L-Proline is a high-purity chiral proline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for the development of complex pharmaceutical compounds, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates. This product is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require high-quality, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex APIs and investigational new drugs.
• Peptidomimetics Research: Used in the design and synthesis of proline-based peptide analogs and enzyme inhibitors.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or organocatalysts used in stereoselective transformations.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry: Serves as a starting material for scaling up the production of target molecules under GMP or non-GMP conditions.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and novel chemical entities.

Basic Information

Item	Detail
Product Name	1-[(2R)-3-Hydroxy-2-Methyl-1-Oxopropyl]-L-Proline
CAS No.	613256-52-3
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	(2R)-1-[(2S)-2-Methyl-3-oxopropanoyl]pyrrolidine-2-carboxylic acid; (R)-1-((S)-2-Methyl-3-oxopropanoyl)pyrrolidine-2-carboxylic acid; L-Proline, 1-[(2R)-3-hydroxy-2-methyl-1-oxopropyl]-; Chiral Proline Ester Derivative; Hydroxy-Methyl-Oxopropyl Proline; Proline Lactone Derivative; CAS 613256-52-3
EINECS	Contact for details

Quality Control

Our 1-[(2R)-3-Hydroxy-2-Methyl-1-Oxopropyl]-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.