Description

(Deamino-Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-Msh (3-11) Amide CAS NO 613222-50-7 is a synthetic, biologically active peptide analog derived from the α-Melanocyte-Stimulating Hormone (α-MSH) sequence. This compound is engineered for enhanced stability and receptor binding affinity, making it a critical research tool for studying melanocortin receptor pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotech companies engaged in metabolic, inflammatory, and dermatological research, as well as in the development of novel therapeutic agents.

Application

• Biomedical Research: A key ligand for in vitro and in vivo studies targeting melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for metabolic and anti-inflammatory drugs.
• Mechanistic Studies: Investigating the role of α-MSH pathways in appetite regulation, energy homeostasis, pigmentation, and immunomodulation.
• Analytical Standard: Serves as a high-purity standard for method development and validation in analytical techniques like HPLC and LC-MS.
• Peptide Chemistry Reference: Used in studies focusing on structure-activity relationships (SAR) of modified peptide sequences.

Basic Information

Product Name	(Deamino-Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-Msh (3-11) Amide
CAS No.	613222-50-7
Molecular Formula	C58H84N18O12S2
Molecular Weight	1281.5 g/mol
Synonyms	SHU-9119; [D-2-Nal7]-α-MSH (3-11) amide; Melanotan II Antagonist; Ac-Nle-c[Asp-His-D-2-Nal-Arg-Trp-Lys]-NH2; MC3/4R Antagonist; α-MSH (3-11) amide analog; Cyclic α-MSH antagonist; (Deamino-Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-Melanocyte Stimulating Hormone (3-11) amide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of (Deamino-Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-Msh (3-11) Amide is subjected to rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, content, and analytical results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.