Description

(3S,3'S,4S,4'S,11Bs,11'Bs)-(+)-4,4'-Di-T-Butyl-4,4',5,5'-Tetrahydro-3,3'-Bi-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepin is a high-value, chiral phosphine ligand with a unique, sterically demanding binaphthyl backbone. This compound is critical for enabling highly selective and efficient catalytic transformations in asymmetric synthesis. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: As a privileged ligand for transition metal catalysts (e.g., Rh, Pd, Ru) in enantioselective hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Synthesis: For the production of chiral drug molecules, including those for cardiovascular, central nervous system, and antiviral therapies.
• Agrochemical Development: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: As a building block or chiral inducer in the development of advanced functional materials.
• Methodology Development: A key tool for academic and industrial chemists developing new catalytic asymmetric methodologies.
• Process Chemistry: Scaling up enantioselective routes for cost-effective and sustainable manufacturing of fine chemicals.

Basic Information

Product Name	(3S,3'S,4S,4'S,11Bs,11'Bs)-(+)-4,4'-Di-T-Butyl-4,4',5,5'-Tetrahydro-3,3'-Bi-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepin
CAS No.	610304-81-9
Molecular Formula	C34H36P2
Molecular Weight	506.59 g/mol
Synonyms	(+)-DTB-BINAP; (S,S)-DTB-BINAP; (S)-DTB-BINAP; 4,4'-Di-tert-butyl-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; (R)-4,4'-Di-tert-butyl-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (enantiomer); (3S,3'S,4S,4'S,11Bs,11'Bs)-4,4'-Di-tert-butyl-4,4',5,5'-tetrahydro-3,3'-bi-3H-dinaphtho[2,1-c:1',2'-e]phosphepin; DTB-BINAP ligand; DTBBINAP
EINECS	Contact for details

Quality Control

Our (3S,3'S,4S,4'S,11Bs,11'Bs)-(+)-4,4'-Di-T-Butyl-4,4',5,5'-Tetrahydro-3,3'-Bi-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding catalytic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain optimal catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.