Description

4-Amino-2-(Trifluoromethoxy)Benzonitrile is a high-value aromatic nitrile derivative featuring both an amino group and a trifluoromethoxy substituent, making it a versatile and sought-after building block in advanced chemical synthesis. Its unique structure offers significant potential for modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Used in the research and production of specialty electronic chemicals, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic and polarizable nature.
• Polymer & Resin Modifiers: Acts as a monomer or cross-linking agent in the synthesis of high-performance polymers, coatings, and adhesives requiring specific thermal or chemical resistance.
• Dye & Pigment Intermediate: Employed in the synthesis of complex dyes, pigments, and optical brighteners where the amino and cyano groups provide reactive sites for chromophore development.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new reaction pathways and creating compound libraries for high-throughput screening.

Basic Information

Product Name	4-Amino-2-(Trifluoromethoxy)Benzonitrile
CAS No.	609783-06-4
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	2-Amino-4-cyano-1-(trifluoromethoxy)benzene; 2-Cyano-5-(trifluoromethoxy)aniline; 4-Cyano-3-(trifluoromethoxy)aniline; Benzonitrile, 4-amino-2-(trifluoromethoxy)-; 4-Amino-2-(trifluoromethoxy)benzonitrile; 2-(Trifluoromethoxy)-4-aminobenzonitrile; 5-Amino-2-(trifluoromethoxy)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-2-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.