Description

Methyl 4-(2-Fluorophenyl)-2,4-Dioxobutanoate is a high-purity fluorinated organic building block, specifically a β-keto ester derivative, essential for advanced synthetic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorophenyl moiety is a critical structural component.
• Chemical Research & Development: Serves as a versatile precursor for heterocyclic chemistry, including the synthesis of pyrazoles, isoxazoles, and other nitrogen-containing rings via reactions with hydrazines and hydroxylamines.
• Material Science Precursor: Potential intermediate for the development of specialty polymers, ligands for catalysis, or organic electronic materials due to its conjugated dioxobutanoate structure.
• Cross-Coupling Reactions: The aromatic ring can be further functionalized via palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex molecular architectures.

Basic Information

Product Name	Methyl 4-(2-Fluorophenyl)-2,4-Dioxobutanoate
CAS No.	608536-99-8
Molecular Formula	C11H9FO4
Molecular Weight	224.19 g/mol
Synonyms	Methyl 2-Fluoro-β-oxobenzeneacetate; Methyl (2-Fluorobenzoyl)acetate; 2,4-Dioxo-4-(2-fluorophenyl)butyric Acid Methyl Ester; 4-(2-Fluorophenyl)-2,4-dioxobutanoic Acid Methyl Ester; 2-Fluorophenyl 2,4-Dioxobutanoate Methyl Ester; Acetic acid, (2-fluorobenzoyl)-, methyl ester; Methyl 3-oxo-3-(2-fluorophenyl)propanoate (tautomeric form)
EINECS	Contact for details

Quality Control

Our Methyl 4-(2-Fluorophenyl)-2,4-Dioxobutanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.