Description

Fmoc-Asp(Ofm)-Oh is a protected aspartic acid derivative, a crucial building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy, where the Fmoc group shields the α-amino group and the OFm (9-fluorenylmethyl) ester protects the β-carboxylic acid side chain, enabling selective deprotection for complex peptide assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential incorporation of aspartic acid into peptide chains using Fmoc chemistry.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, hormones, and enzyme inhibitors where precise aspartic acid placement is critical.
• Bioconjugation: Used to introduce aspartic acid residues into proteins or other molecules for labeling, cross-linking, or modifying biological activity.
• Combinatorial Chemistry: Building block in libraries for high-throughput screening to discover new bioactive compounds.
• Material Science: Synthesis of aspartic acid-containing polymers and smart materials with specific functional properties.

Basic Information

Product Name	Fmoc-Asp(Ofm)-Oh
CAS No.	608512-85-2
Molecular Formula	C₂₈H₂₅NO₆
Molecular Weight	471.50 g/mol
Synonyms	Fmoc-Asp(OFm)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid β-(9-fluorenylmethyl) ester; Fmoc-L-Asp(OFm)-OH; Fmoc-Aspartic acid(OFm)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-(9H-fluoren-9-ylmethyl) ester; Nα-Fmoc-Nβ-Ofm-L-aspartic acid; Fmoc-Asp-OFm; Fmoc-Asp(9-Fm)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Ofm)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.