Description

Fmoc-3-[[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)-3-Methylbutyl]Amino]-L-Alanine is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for introducing specific steric and functional constraints into peptide backbones, enabling the development of novel bioactive molecules with enhanced stability and selectivity. It is primarily utilized by research scientists and process chemists in pharmaceutical R&D, biotechnology, and academic institutions focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the controlled incorporation of a constrained amino acid analog into peptide chains.
• Peptidomimetic Design: For creating conformationally restricted peptides that mimic natural protein structures, improving metabolic stability and receptor binding affinity.
• Medicinal Chemistry Research: A key intermediate in the synthesis of potential therapeutic peptides targeting GPCRs, enzymes, and protein-protein interactions.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying biological pathways and mechanisms of action.
• Process Development: Serves as a high-purity intermediate in the scale-up and optimization of peptide active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Fmoc-3-[[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)-3-Methylbutyl]Amino]-L-Alanine
CAS No.	607366-20-1
Molecular Formula	C31H36N2O6
Molecular Weight	532.63 g/mol
Synonyms	Fmoc-Dde-L-Ala-OH; Fmoc-L-Ala(Dde)-OH; N-α-Fmoc-N-β-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)-L-α,β-diaminopropionic Acid; Fmoc-3-[(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino]-L-alanine; N-α-(9-Fluorenylmethoxycarbonyl)-N-β-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-α,β-diaminopropionic Acid; Fmoc-Ala(Dde)-OH; Fmoc-Dde-Ala-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3-[[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)-3-Methylbutyl]Amino]-L-Alanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.