Description

H2N-L-Pro-Ome CAS NO 604003-91-0 is a protected amino acid derivative, specifically the methyl ester of L-Proline with a free amine group. This high-purity building block is critical for the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is an essential intermediate for pharmaceutical research, particularly in developing active pharmaceutical ingredients (APIs) and novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides.
• API Development: Used in research and development of new Active Pharmaceutical Ingredients (APIs), especially those containing proline motifs.
• Peptidomimetics Synthesis: Serves as a precursor for creating non-natural peptide analogs with enhanced stability and bioavailability.
• Bioconjugation: The free amine group allows for site-specific conjugation with other molecules, such as dyes, polymers, or drug carriers.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: Supplied to CROs and CDMOs for the production of custom peptide sequences for clients.

Basic Information

Product Name	H2N-L-Pro-Ome
CAS No.	604003-91-0
Molecular Formula	C6H12N2O2
Molecular Weight	144.17 g/mol
Synonyms	L-Proline methyl ester; (S)-Methyl 2-aminopyrrolidine-1-carboxylate; H-Pro-OMe; H-L-Pro-OMe; Proline methyl ester hydrochloride (precursor form); Methyl L-prolinate; 1-Carbomethoxy-2-aminopyrrolidine; Fmoc-Pro-OMe (related protected form)
EINECS	Contact for details

Quality Control

Our H2N-L-Pro-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.