Description

4-Chloro-2-(Trifluoromethyl)Phenylacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents on the phenylacetic acid core, makes it a versatile intermediate for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, CNS disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and plant growth regulators, where the trifluoromethyl group enhances bioactivity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for synthesizing fluorinated aromatic components used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Advanced Polymer Modification: Employed to introduce fluorinated phenylacetic acid moieties into polymer backbones, imparting specific properties like chemical resistance, thermal stability, or altered surface energy.
• Chemical Research & Development: A valuable reagent for method development, catalysis studies, and exploring new reaction pathways in academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers for the production of specialized, high-value compounds under cGMP or other stringent quality frameworks.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Phenylacetic Acid
CAS No.	601513-31-9
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	2-(4-Chloro-2-(trifluoromethyl)phenyl)acetic acid; [4-Chloro-2-(trifluoromethyl)phenyl]acetic acid; 4-Chloro-α-(trifluoromethyl)benzeneacetic acid; 4-Chloro-2-trifluoromethylphenylacetic acid; 2-(4-Chloro-2-trifluoromethylphenyl)acetic Acid; 4-Chloro-α,α,α-trifluoro-o-tolylacetic acid; (4-Chloro-2-(trifluoromethyl)phenyl)ethanoic acid
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-2-(Trifluoromethyl)Phenylacetic Acid adheres to a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, appropriate chemical-resistant materials should be used for handling and storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.