Description

L-Eflornithine Monohydrochloride is a highly specific, irreversible inhibitor of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis. This mechanism of action makes it a critical compound for research and development in targeted therapeutic areas. It is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies focused on dermatology, oncology, and parasitology. Our supply is characterized by stringent quality control and reliable batch-to-batch consistency to support your critical applications.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of topical creams for the treatment of hirsutism (excessive hair growth).
• Oncology Research: Investigated for its potential antiproliferative effects in cancer research due to its role in inhibiting polyamine synthesis essential for cell growth.
• Antiparasitic Development: Used in research for developing treatments against African trypanosomiasis (sleeping sickness) as it inhibits a critical pathway in the Trypanosoma parasite.
• Biochemical Research: Serves as a standard and tool compound in enzymatic studies focusing on ornithine decarboxylase activity and polyamine metabolism.
• Dermatology R&D: Employed in developing new therapeutic agents for skin conditions where regulation of cell proliferation is desired.
• Reference Standard: Used in analytical laboratories for quality control and method development via HPLC, LC-MS, or NMR.

Basic Information

Product Name	L-Eflornithine Monohydrochloride
CAS No.	69955-42-6
Molecular Formula	C6H15ClF2N2O2
Molecular Weight	220.65 g/mol
Synonyms	Eflornithine HCl; DFMO Hydrochloride; (2S)-2-Amino-5-[(2R)-2-amino-5-fluoropentyl]amino-2-fluoropentanoic acid hydrochloride; L-α-Difluoromethylornithine monohydrochloride; Ornidyl; CGP 32411A; (±)-Eflornithine hydrochloride; RMI-71782
EINECS	Contact for details

Quality Control

Our L-Eflornithine Monohydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with relevant pharmacopeial monographs upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Optical Rotation [α]D20	+14.0° to +18.0° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.