Description

α-Difluoromethyl-Dopa is a fluorinated derivative of the amino acid L-Dopa, characterized by the strategic substitution of hydrogen atoms with fluorine on the methyl group. This modification is designed to enhance metabolic stability and alter biological activity, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and research organizations focused on creating novel therapeutic agents, particularly for neurological and cardiovascular applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated drug candidates targeting the central nervous system.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on drug potency, selectivity, and pharmacokinetics.
• Enzyme Inhibition Studies: Serves as a potential precursor for developing mechanism-based enzyme inhibitors, particularly for decarboxylase enzymes.
• Preclinical Development: Employed in the early-stage development of new chemical entities (NCEs) for various therapeutic areas.
• Reference Standard: Used as an analytical standard in quality control and method development for related pharmaceutical compounds.

Basic Information

Product Name	α-Difluoromethyl-Dopa
CAS No.	69955-03-9
Molecular Formula	C10H11F2NO4
Molecular Weight	247.20 g/mol
Synonyms	(S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-difluoromethylpropanoic acid; 2-Difluoromethyl-3-(3,4-dihydroxyphenyl)-L-alanine; L-α-(Difluoromethyl)dopa; DFMD; α-DFMD; (2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-(difluoromethyl)propanoic acid
EINECS	Contact for details

Quality Control

Our α-Difluoromethyl-Dopa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (IR, NMR). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.