Description

3-Hydroxy-3-Ethylglutaryl-Coenzyme A is a key biochemical intermediate in the mevalonate pathway, essential for the biosynthesis of isoprenoids and sterols. This high-purity compound is critical for research and development in metabolic studies, enzyme kinetics, and pharmaceutical discovery. It serves as a vital reagent for biochemists, enzymologists, and pharmaceutical scientists working on cholesterol metabolism, drug target validation, and biosynthesis pathway analysis.

Application

• Enzymology Research: Used as a specific substrate for studying HMG-CoA synthase and related enzymes in the mevalonate pathway.
• Metabolic Pathway Analysis: Essential for in vitro and cell-based studies investigating sterol and isoprenoid biosynthesis regulation.
• Pharmaceutical Development: Serves as a key intermediate and reference standard in the discovery of novel lipid-lowering agents and metabolic disorder therapeutics.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays for enzyme inhibitors.
• Academic Research: A fundamental tool for university and institutional research into cellular metabolism and bioenergetics.
• Diagnostic Reagent Manufacturing: Used in the formulation of specialized diagnostic kits for metabolic function testing.

Basic Information

Product Name	3-Hydroxy-3-Ethylglutaryl-Coenzyme A
CAS No.	69925-08-2
Molecular Formula	C28H46N7O19P3S
Molecular Weight	909.68 g/mol
Synonyms	HMG-CoA; 3-Hydroxy-3-methylglutaryl-CoA (common misnomer for the ethyl analog); 3-Ethyl-3-hydroxyglutaryl-CoA; (3R)-3-Hydroxy-3-ethylglutaryl-CoA; 3-Hydroxy-3-ethylglutaryl-coenzyme A; Coenzyme A, S-[3-hydroxy-3-ethyl-1,5-pentanediyl] ester; HMG-CoA analog; 3-Ethyl-HMG-CoA
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Ethylglutaryl-Coenzyme A is manufactured under stringent quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We adhere to cGMP guidelines for the production of high-value biochemical intermediates, ensuring traceability and documentation for regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot contents to minimize repeated freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Conforms (Enzymatic Assay)
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.