Description

3,5-Bis(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters because its pinacol ester group provides enhanced stability and handling characteristics compared to the free boronic acid, making it an indispensable reagent for demanding cross-coupling reactions. It is primarily needed by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules containing the robust 3,5-bis(trifluoromethyl)phenyl moiety.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs), especially those requiring the lipophilic and electron-withdrawing bis(trifluoromethyl)phenyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance compound activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a building block for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Advanced Material Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) for electronic and photonic applications.
• Chemical Research & Development: An essential reagent in academic and industrial labs for exploring new C-C bond-forming methodologies and creating compound libraries for screening.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	69807-91-6
Molecular Formula	C14H15BF6O2
Molecular Weight	340.08 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]boronic acid pinacol ester; Pinacol [3,5-bis(trifluoromethyl)phenyl]boronate; 3,5-Bis(trifluoromethyl)benzeneboronic acid pinacol ester; B-[3,5-Bis(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,5-Bis(trifluoromethyl)phenylboronic acid, pinacol ester; 4,4,5,5-Tetramethyl-2-[3,5-bis(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 3,5-Di(trifluoromethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistent performance in sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your internal specifications and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.