Description

Cefotetan CAS NO 69712-56-7 is a second-generation cephalosporin antibiotic belonging to the cephamycin class, characterized by its broad-spectrum activity against Gram-positive and Gram-negative bacteria. Its core value proposition lies in its stability against β-lactamase enzymes, making it a critical agent for treating serious infections, particularly in surgical prophylaxis and intra-abdominal infections. This product is essential for pharmaceutical manufacturers and research institutions involved in developing and producing sterile injectable antibiotic formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of sterile injectable antibiotic formulations.
• Surgical Prophylaxis: Key component in antibiotics administered pre-operatively to prevent post-surgical infections, particularly in colorectal, obstetric, and gynecologic surgeries.
• Treatment of Intra-abdominal Infections: Effective against mixed aerobic and anaerobic bacteria commonly found in peritonitis and other abdominal infections.
• Gynecological and Obstetric Infections: Used in the management of pelvic inflammatory disease, endometritis, and post-partum infections.
• Urinary Tract Infections (UTIs): Treatment of complicated UTIs caused by susceptible organisms.
• Skin and Skin Structure Infections: Management of moderate to severe infections, including those from surgical sites.
• Research & Development: Serves as a reference standard and starting material for pharmacological studies and new drug development.
• Veterinary Medicine: Potential application in treating bacterial infections in animals under veterinary guidance.

Basic Information

Product Name	Cefotetan
CAS No.	69712-56-7
Molecular Formula	C17H17N7O8S4
Molecular Weight	575.62 g/mol
Synonyms	(6R,7S)-7-[[(4-(2-Amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotetan Disodium; Apatef; Cefotan; Yamatetan; Ceftenon; CMT; 6α-Methoxy-7β-[2-(2-amino-4-carboxy-1,3-dithietan-2-ylidene)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid
EINECS	274-125-6

Quality Control

Our Cefotetan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing parameters such as assay, purity, and impurity profiles. We can support compliance with relevant pharmacopoeial standards (e.g., USP, EP, JP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Specific Optical Rotation	-45° to -55° (c=1 in water)
pH (1% solution)	4.5 - 6.5
Bacterial Endotoxins	< 0.10 EU/mg (for injectable grade)
Sterility	Conforms (for sterile grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.