Description

Low Affinity Platelet Factor 4 is a specific isoform of the PF4 protein, a key chemokine released from platelet α-granules. This product is essential for researchers and developers in the life sciences sector, particularly for studies involving heparin-induced thrombocytopenia (HIT) and other platelet-related immune responses. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic institutions focused on hematology and immunology research.

Application

• Heparin-Induced Thrombocytopenia (HIT) Research: Critical for in vitro studies to understand the immune complex formation between PF4 and heparin.
• Diagnostic Assay Development: Used as a key antigenic component in the development and calibration of immunoassays for detecting HIT antibodies.
• Platelet Biology Studies: Employed to investigate the role of PF4 isoforms in platelet activation, aggregation, and inflammatory processes.
• Biomarker Investigation: Serves as a reference standard in proteomic and clinical studies exploring PF4 as a potential biomarker for vascular diseases.
• Therapeutic Antibody Screening: Used in high-throughput screening platforms to identify and characterize novel therapeutic antibodies targeting PF4-heparin complexes.
• Quality Control for Biologics: Acts as a reference material in the QC testing of heparin-based pharmaceuticals to assess potential immunogenic risks.

Basic Information

Product Name	Low Affinity Platelet Factor 4
CAS No.	69670-74-2
Molecular Formula	C~170H~270N~50O~55S~2 (Approximate for protein)
Molecular Weight	~7.8 kDa (Monomer)
Synonyms	Platelet Factor 4 Variant; PF4-LA; Low-Affinity PF4; CXCL4 Isoform; Chemokine (C-X-C motif) ligand 4 variant; Oncostatin A; SCYB4; Iroplact; Thrombocytin
EINECS	Contact for details

Quality Control

Our Low Affinity Platelet Factor 4 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity. Quality is assured through rigorous testing protocols, including SDS-PAGE, HPLC, and functional immunoassays, meeting the exacting standards required for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Avoid repeated freeze-thaw cycles to maintain stability and activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Protein Content (UV)	≥ 90%
Biological Activity (ELISA)	Conforms to reference activity
Endotoxin	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.