Description

Substance P (1-4) CAS NO 69355-89-1 is a specific, biologically active fragment of the full neuropeptide Substance P. This compound is a critical research tool for studying neurokinin-1 (NK1) receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neuroscience, pain management, and inflammatory processes.

Application

• Neuroscience Research: Used as a standard or reference compound in studies of neuropeptide function, synaptic transmission, and central nervous system signaling.
• Receptor Binding Assays: Essential for competitive binding studies to characterize NK1 receptor affinity, selectivity, and the development of receptor antagonists.
• Biochemical Pathway Analysis: Employed to investigate intracellular signaling cascades triggered by Substance P fragment activation in various cell lines.
• Drug Discovery & Development: Serves as a key pharmacological tool in high-throughput screening (HTS) campaigns and preclinical validation for pain, inflammation, and mood disorder therapeutics.
• Academic & Clinical Studies: Facilitates fundamental research into the role of tachykinins in physiological and pathophysiological conditions.

Basic Information

Product Name	Substance P (1-4)
CAS No.	69355-89-1
Molecular Formula	C24H38N8O6
Molecular Weight	534.61 g/mol
Synonyms	Substance P Fragment 1-4; Arg-Pro-Lys-Pro; SP(1-4); H-Arg-Pro-Lys-Pro-OH; Tachykinin Fragment 1-4; Neurokinin P (1-4); RPKP; Substance P (1-4) amide (common variant)
EINECS	Contact for details

Quality Control

Our Substance P (1-4) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through comprehensive analytical techniques including HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.