Description

4,4,4-Trifluoro-2-(2-Methoxyethyl)-3-Oxobutyric Acid Ethyl Ester is a high-value fluorinated organic building block with a unique trifluoromethyl ketone ester structure. This compound is essential for introducing the metabolically stable trifluoromethyl group into target molecules, significantly enhancing their lipophilicity and biological activity. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in protease inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the CF3 group improves efficacy and environmental stability.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and specialty coatings with enhanced chemical and thermal resistance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Michael additions, and other transformations to construct complex fluorinated molecular architectures.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological mechanisms and enzyme activity.

Basic Information

Product Name	4,4,4-Trifluoro-2-(2-Methoxyethyl)-3-Oxobutyric Acid Ethyl Ester
CAS No.	69243-08-9
Molecular Formula	C9H13F3O4
Molecular Weight	242.19 g/mol
Synonyms	Ethyl 4,4,4-trifluoro-2-(2-methoxyethyl)-3-oxobutanoate; Ethyl 4,4,4-Trifluoro-3-oxo-2-(2-methoxyethyl)butyrate; 3-Oxobutyric Acid, 4,4,4-Trifluoro-2-(2-Methoxyethyl)-, Ethyl Ester; 4,4,4-Trifluoro-2-(2-Methoxyethyl)-3-Oxobutanoic Acid Ethyl Ester; 2-(2-Methoxyethyl)-4,4,4-trifluoro-3-oxobutyric acid ethyl ester; TFMOEBE; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-2-(2-Methoxyethyl)-3-Oxobutyric Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.