Description

5-(((Carboxymethyl)Amino)Methyl)Uridine is a modified nucleoside building block of significant interest in advanced biochemical research and pharmaceutical development. This compound is valued for its unique structure, which incorporates a carboxymethylamino-methyl side chain, enabling its use in the synthesis of sophisticated oligonucleotide analogs and bioconjugates. It serves as a critical intermediate for researchers and manufacturers in the fields of nucleic acid chemistry, prodrug design, and medicinal chemistry, particularly for creating targeted therapeutic agents and diagnostic probes.

Application

• Oligonucleotide Synthesis: A key modified monomer for introducing functional handles into DNA/RNA strands for labeling, conjugation, or therapeutic enhancement.
• Antiviral & Anticancer Prodrug Development: Serves as a building block in the design of nucleoside-based prodrugs aimed at improving bioavailability and targeting.
• Bioconjugation & Linker Chemistry: The carboxylic acid group provides a versatile site for coupling to peptides, proteins, or other molecules via amide bond formation.
• Chemical Biology Research: Used in the study of nucleic acid structure, function, and interactions, as well as in the development of novel biosensors.
• Pharmaceutical Intermediates: An important precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) targeting various diseases.

Basic Information

Product Name	5-(((Carboxymethyl)Amino)Methyl)Uridine
CAS No.	69181-26-6
Molecular Formula	C10H15N3O8
Molecular Weight	305.24 g/mol
Synonyms	5-[(Carboxymethylamino)methyl]uridine; 5-(N-Carboxymethylaminomethyl)uridine; Uridine, 5-[(carboxymethylamino)methyl]-; 5-Carbamoylmethylaminomethyluridine; CMAM-uridine; 5-(((Carboxymethyl)amino)methyl)-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-(((Carboxymethyl)Amino)Methyl)Uridine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data. Specifications are designed to meet the rigorous demands of pharmaceutical intermediate and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.