Description

Cefotaxime Syn S-Oxide is a key intermediate in the synthesis of the third-generation cephalosporin antibiotic, Cefotaxime. This compound is critical for ensuring the purity, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced β-lactam antibiotics and related fine chemicals.

Application

• Pharmaceutical Intermediate: Primary use as a high-purity synthetic precursor in the commercial production of Cefotaxime Sodium API.
• Research & Development: Serves as a critical reference standard and building block in medicinal chemistry for developing novel cephalosporin derivatives.
• Quality Control: Used as an analytical standard in HPLC and other chromatographic methods to monitor synthesis processes and impurity profiles.
• Process Chemistry: Integral to optimizing and scaling up synthesis routes for Cefotaxime and related antibiotics in GMP environments.

Basic Information

Item	Details
Product Name	Cefotaxime Syn S-Oxide
CAS No.	69132-42-9
Molecular Formula	C16H17N5O8S2
Molecular Weight	479.47 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid S-Oxide; Cefotaxime S-Oxide; Syn Isomer of Cefotaxime S-Oxide; Cefotaxime Sulfoxide; (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 5-Oxide
EINECS	Contact for details

Quality Control

Our Cefotaxime Syn S-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.