Description

Pth (1-84) (Human) is a synthetic polypeptide fragment corresponding to the first 84 amino acids of the human parathyroid hormone. This bioactive peptide is a critical research tool for studying calcium and phosphate metabolism, bone remodeling, and endocrine signaling pathways. It is essential for researchers and developers in the fields of endocrinology, osteoporosis research, and peptide-based therapeutic development. The compound is supplied as a high-purity, lyophilized powder, with CAS No. 68893-82-3.

Application

• Biomedical Research: Used as a standard and reagent in studies of parathyroid hormone (PTH) receptor binding, signal transduction, and biological activity.
• Drug Discovery & Development: Serves as a reference compound and starting material for the development of PTH analogs and related therapeutics for bone disorders.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to detect PTH levels in clinical samples.
• Cell Culture & In Vitro Studies: Applied to stimulate osteoblast activity and investigate bone formation mechanisms in cellular models.
• Academic & Pharmaceutical R&D: A fundamental tool for investigating the pathophysiology of hyperparathyroidism, hypoparathyroidism, and metabolic bone diseases.

Basic Information

Product Name	Pth (1-84) (Human)
CAS No.	68893-82-3
Molecular Formula	C~410~H~670~N~124~O~126~S~2
Molecular Weight	~9427.8 g/mol
Synonyms	Human Parathyroid Hormone (1-84); hPTH(1-84); Parathyrin (1-84); PTH Human; Parathyroid Hormone Fragment 1-84; Intact PTH; Endogenous Parathyroid Hormone; PTH (1–84) (human)
EINECS	Contact for details

Quality Control

Our Pth (1-84) (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. Specifications typically meet or exceed standards required for research and in vitro diagnostic use. A detailed Certificate of Analysis (COA) providing results for purity (HPLC), peptide content, amino acid analysis, and mass spectrometry is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Reconstituted solutions should be aliquoted and stored at -20°C or -80°C for short-term use; avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.