Description

Fmoc-L-Valine CAS NO 68858-20-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a critical building block for the controlled, sequential assembly of peptides, ensuring high coupling efficiency and minimal racemization. This compound is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs engaged in the development of therapeutic peptides, peptide hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the stepwise construction of custom peptide sequences in automated synthesizers.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including metabolic regulators, antimicrobial peptides, and oncology treatments.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of peptide compounds for high-throughput screening in drug discovery programs.
• Bioconjugation and Labeling: Acts as a precursor for introducing valine residues into biomolecules for conjugation with drugs, probes, or reporter molecules.
• Academic and Industrial Research: Essential for biochemical studies investigating protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Peptide Fragments: Used in the synthesis of specific peptide segments for fragment condensation or native chemical ligation strategies.

Basic Information

Product Name	Fmoc-L-Valine
CAS No.	68858-20-8
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39 g/mol
Synonyms	N-(9-Fluorenylmethoxycarbonyl)-L-valine; Fmoc-Val-OH; (2S)-3-Methyl-2-[(9H-fluoren-9-ylmethoxy)formamido]butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine; Fmoc-L-valine; Fmoc-Val; L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-L-valine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Valine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles for pharmaceutical-grade materials, and our quality systems support compliance with major pharmacopoeial standards (USP/EP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-14.0° to -16.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.