Description

3(R)-Fluoro-D-Aspartic Acid is a fluorinated derivative of the D-enantiomer of aspartic acid, a non-proteinogenic amino acid. This compound is a valuable chiral building block and biochemical tool, prized for its role in modulating glutamate receptor activity and metabolic pathways. It is essential for researchers and manufacturers in pharmaceutical development, neuroscience research, and the synthesis of advanced peptide-based therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly those targeting neurological disorders.
• Biochemical Research: Used as a selective inhibitor or substrate analog in studies of enzyme kinetics, glutamate transporters (EAATs), and NMDA receptor function.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) or to create fluorinated peptide libraries with enhanced metabolic stability.
• Metabolic Pathway Probing: Serves as a tracer or inhibitor in metabolic studies to investigate aspartate and glutamate utilization in cells.
• Diagnostic Agent Development: A potential precursor for radiolabeling (e.g., with F-18) to create Positron Emission Tomography (PET) tracers for imaging.
• Academic & Contract Research: Supplied to universities and CROs for fundamental research in medicinal chemistry and neuropharmacology.

Basic Information

Item	Detail
Product Name	3(R)-Fluoro-D-Aspartic Acid
CAS No.	68832-50-8
Molecular Formula	C4H6FNO4
Molecular Weight	151.09 g/mol
Synonyms	(R)-3-Fluoro-D-aspartic Acid; D-3-Fluoroaspartic Acid; (2R)-2-Amino-3-fluorobutanedioic Acid; 3-Fluoro-D-aspartate; 3F-D-Asp; Fluor-D-Asp; 3(R)-F-D-Asp; (R)-3-Fluoroaspartic Acid
EINECS	Contact for details

Quality Control

Our 3(R)-Fluoro-D-Aspartic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high chemical and chiral purity, meeting the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.