Description

β-Fluoroaspartic Acid is a fluorinated derivative of the essential amino acid aspartic acid, where a fluorine atom is strategically substituted at the β-carbon position. This structural modification makes it a valuable non-hydrolyzable mimic and a critical building block in medicinal chemistry and biochemical research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on enzyme inhibition studies, metabolic pathway analysis, and the development of novel therapeutic agents.

Application

• Enzyme Inhibitor Development: Serves as a key intermediate in synthesizing potent, mechanism-based inhibitors for aspartate-specific enzymes like aspartate transcarbamoylase.
• Metabolic Pathway Probing: Used as a stable isotopic or fluorinated tracer to study the urea cycle and other aspartate-involved metabolic processes.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance metabolic stability, alter binding affinity, and investigate structure-activity relationships (SAR).
• Neurological Research: Acts as a tool compound in studies related to excitatory amino acid transporters (EAATs) and neurotransmission.
• Chemical Biology Probes: Utilized for labeling and activity-based protein profiling (ABPP) to discover and validate new drug targets.
• Academic & Pharmaceutical R&D: A fundamental research chemical for exploring fluorination effects on amino acid reactivity and biological activity.

Basic Information

Product Name	β-Fluoroaspartic Acid
CAS No.	68832-48-4
Molecular Formula	C4H6FNO4
Molecular Weight	151.09 g/mol
Synonyms	(2S)-2-Amino-3-fluorobutanedioic Acid; (S)-2-Amino-3-fluorosuccinic Acid; 3-Fluoro-L-aspartic Acid; L-β-Fluoroaspartate; L-3-Fluoroaspartic Acid; F-Asp; β-F-Asp; FLUORO-DL-ASPARTIC ACID (mixture of isomers)
EINECS	Contact for details

Quality Control

Our β-Fluoroaspartic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.