Description

Cocarboxylase Tetrahydrate is the stable, hydrated form of thiamine pyrophosphate (TPP), the biologically active coenzyme of vitamin B1. This compound is essential for critical enzymatic reactions in carbohydrate metabolism, particularly in the decarboxylation of α-keto acids. It is a vital raw material for the pharmaceutical, nutraceutical, and research sectors, where precise biochemical activity is required. Global industries rely on it for manufacturing injectable formulations, advanced cell culture media, and high-purity enzymatic supplements.

Application

• Pharmaceutical Active Ingredient: Used in the synthesis of injectable preparations for treating conditions like Wernicke's encephalopathy and severe thiamine deficiency.
• Biochemical Research & Diagnostics: Serves as a critical cofactor in enzyme assays, metabolic pathway studies, and diagnostic kit formulations.
• Cell Culture & Fermentation: An essential component of specialized cell culture media and fermentation broths to support optimal cellular growth and metabolism.
• Nutraceutical & Cosmetic Formulations: Incorporated into high-end dietary supplements and cosmetic products for its role in cellular energy production.
• Veterinary Medicine: Used in animal health products to address metabolic disorders and support energy metabolism in livestock and pets.
• Enzyme Stabilization: Employed to stabilize and activate pyruvate decarboxylase and transketolase enzymes in industrial biocatalysis.

Basic Information

Product Name	Cocarboxylase Tetrahydrate
CAS No.	68684-55-9
Molecular Formula	C12H22ClN4O7P2S • 4H2O
Molecular Weight	568.79 g/mol (tetrahydrate)
Synonyms	Thiamine Pyrophosphate Chloride Tetrahydrate; TPP; Thiamine Diphosphate; Vitamin B1 Pyrophosphate; Cocarboxylase; Thiamine Pyrophosphate Chloride; Aneurinpyrophosphate; Diphosphothiamine; Berolase; Cofarboxylase
EINECS	Contact for details

Quality Control

Our Cocarboxylase Tetrahydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, specific optical rotation, and tests for related substances and residual solvents, ensuring it meets stringent standards for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Specific Optical Rotation	Contact for details
Water (Karl Fischer)	10.0% - 13.0% (Theoretical for Tetrahydrate: ~12.7%)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.5 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.