Description

3-(2-Iodoacetamidomethyl)-Proxyl is a nitroxide spin label reagent featuring a reactive iodoacetamide group. This compound is essential for site-directed spin labeling (SDSL) in electron paramagnetic resonance (EPR) spectroscopy, enabling the study of protein structure, dynamics, and conformational changes. It is primarily used by researchers and manufacturers in the fields of structural biology, biophysics, and pharmaceutical development for probing biomolecular interactions.

Application

• Site-Directed Spin Labeling (SDSL) for Electron Paramagnetic Resonance (EPR) spectroscopy studies.
• Probing protein structure, folding, and dynamics by covalent attachment to cysteine residues.
• Investigation of membrane protein topology and conformational changes in solution.
• Research into protein-protein interactions and macromolecular complex assembly.
• Development of molecular sensors and tools for structural biology.
• Use in distance measurements via pulsed EPR techniques like DEER (Double Electron-Electron Resonance).

Basic Information

Product Name	3-(2-Iodoacetamidomethyl)-Proxyl
CAS No.	68643-07-2
Molecular Formula	C11H18IN2O2
Molecular Weight	337.18 g/mol
Synonyms	3-(2-Iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-(Iodoacetamidomethyl)-PROXYL; 3-(Iodoacetamidomethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 3-(Iodoacetamidomethyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; Iodoacetamido-PROXYL; 3-(2-Iodoacetamidomethyl)-PROXYL spin label; 1-Oxyl-2,2,5,5-tetramethyl-δ3-pyrroline-3-methyl iodoacetamide
EINECS	Contact for details

Quality Control

Our 3-(2-Iodoacetamidomethyl)-Proxyl is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other key parameters. We support research and development with materials suitable for advanced spectroscopic studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
EPR Spectroscopy	Conforms
Solubility	Soluble in DMSO, DMF, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.