Description

3-(2-Pyridyldithio)Propanoic Acid is a heterobifunctional crosslinking agent featuring a carboxylic acid group and a reactive pyridyl disulfide moiety. This compound is essential for creating stable, cleavable conjugates in bioconjugation and drug delivery research. It is primarily used by researchers and manufacturers in the pharmaceutical and biotechnology industries for antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization of nanoparticles and biomaterials.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for constructing cleavable, reducible linkages between cytotoxic payloads and monoclonal antibodies.
• Protein and Peptide Modification: Enables site-specific conjugation of peptides, proteins, and enzymes with other molecules via disulfide bond formation.
• Surface Functionalization: Used to modify gold nanoparticles, quantum dots, and other material surfaces with carboxylic acid groups for further coupling.
• Solid-Phase Synthesis: Acts as a building block or linker in the synthesis of complex molecules and peptide constructs.
• Biomaterial Engineering: Facilitates the creation of smart, stimuli-responsive hydrogels and drug delivery systems.
• Diagnostic Reagent Development: Employed in the preparation of labeled probes and assay components for diagnostic applications.

Basic Information

Product Name	3-(2-Pyridyldithio)Propanoic Acid
CAS No.	68617-64-1
Molecular Formula	C8H9NO2S2
Molecular Weight	215.29 g/mol
Synonyms	3-(Pyridin-2-yldisulfanyl)propanoic acid; 2-Pyridyldithiopropionic acid; PDPA; S-(2-Pyridylthio)-3-mercaptopropionic acid; 3-[(2-Pyridinyl)dithio]propanoic acid; 3-(2-Pyridyldithio)propionic acid; Propanoic acid, 3-[(2-pyridinyl)dithio]-; 2-Pyridyl disulfide propionic acid
EINECS	Contact for details

Quality Control

Our 3-(2-Pyridyldithio)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.