Description

Angiotensin II Human Acetate is a synthetic peptide hormone identical to the endogenous vasoconstrictor. This compound is critical for research into cardiovascular physiology, hypertension, and renal function. It serves as an essential biochemical tool for pharmaceutical R&D, academic studies, and diagnostic applications, enabling precise investigation of the renin-angiotensin system.

Application

• Biomedical Research: Used as a standard and agonist in studies of the renin-angiotensin-aldosterone system (RAAS), blood pressure regulation, and vascular biology.
• Pharmaceutical Development: Acts as a key reference compound and pharmacological tool in the discovery and screening of angiotensin receptor blockers (ARBs) and other cardiovascular drugs.
• Diagnostic Assays: Employed as a calibrator and control in immunoassays (e.g., ELISA, RIA) for measuring angiotensin II levels in clinical and research settings.
• Cell Signaling Studies: Utilized to stimulate AT1 and AT2 receptors in cell culture models to study intracellular signaling pathways, gene expression, and cellular responses.
• Physiology & Pharmacology Education: Serves as a teaching reagent in university laboratories for demonstrating hormone action and receptor-ligand interactions.

Basic Information

Product Name	Angiotensin II Human Acetate
CAS No.	68521-88-0
Molecular Formula	C50H71N13O12 • (C2H4O2)x
Molecular Weight	1046.2 g/mol (free base)
Synonyms	Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; Human Angiotensin II; [Asn1, Val5]-Angiotensin II; DRVYIHPF; Hypertensin; Ang II; All-L-Angiotensin II; 1-L-Asparagine-5-L-valineangiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II Human Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and LAL for endotoxin levels, ensuring it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	5 - 15%
Endotoxin (LAL)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.