Description

Clofilium Phosphate is a high-purity, non-halogenated organic phosphate salt with significant pharmacological research applications. This compound is valued for its role as a selective potassium channel blocker in cardiovascular and neurological research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers developing novel therapeutic agents. Our supply ensures consistent quality and reliable availability for critical research and development workflows.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the study of class III antiarrhythmic agents.
• Cardiovascular Pharmacology: Used in preclinical studies to investigate potassium channel (IKr) blockade and its effects on cardiac action potential duration.
• Neurological Research: Employed in experimental models to study the role of potassium channels in neuronal excitability and seizure activity.
• Biochemical Assay Development: Acts as a specific tool compound in high-throughput screening (HTS) assays for ion channel target validation.
• Fine Chemical Synthesis: Used as a specialized building block for the synthesis of more complex molecules in medicinal chemistry programs.
• Academic Research: Supplied to university laboratories for fundamental studies in electrophysiology and molecular pharmacology.

Basic Information

Product Name	Clofilium Phosphate
CAS No.	68379-03-3
Molecular Formula	C₂₁H₃₉ClNO₃P
Molecular Weight	419.96 g/mol
Synonyms	4-Chloro-N,N-diethyl-N-heptylbenzenemethanaminium Phosphate; Clofilium Dihydrogen Phosphate; Clofilium Phosphate Salt; 4-Chloro-N,N-diethyl-N-heptylbenzenemethanaminium Dihydrogen Phosphate; 1-(4-Chlorophenyl)-1-(diethylamino)heptyl Benzoate Phosphate (obsolete); Clofilium; LY150378; Benzenemethanaminium, 4-chloro-N,N-diethyl-N-heptyl-, phosphate (1:1)
EINECS	Contact for details

Quality Control

Our Clofilium Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with research-grade material specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Related Substances (HPLC)	Total impurities <2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.