Description

Lithium n-Ethyl-p-Toluenesulphonamidate is a specialized organolithium reagent used in advanced synthetic chemistry. This compound matters for its role as a powerful base and nucleophile, enabling the formation of complex carbon-carbon and carbon-heteroatom bonds under controlled conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel molecular architectures.

Application

• As a strong, non-nucleophilic base in deprotonation reactions for the generation of enolates and other carbanions.
• As a key reagent in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and intermediates.
• For metallation reactions in the preparation of functionalized aromatic compounds for material science applications.
• In cross-coupling reaction sequences as a transmetallation agent or precursor to other organometallic species.
• For the development of novel ligands and catalysts used in asymmetric synthesis.
• In process chemistry for the scale-up of high-value fine chemicals under inert atmosphere conditions.

Basic Information

Product Name	Lithium n-Ethyl-p-Toluenesulphonamidate
CAS No.	68299-01-4
Molecular Formula	C9H12LiNO2S
Molecular Weight	205.20 g/mol
Synonyms	Lithium N-ethyl-4-methylbenzenesulfonamidate; N-Ethyl-p-toluenesulfonamide, lithium salt; p-Toluenesulfonamide, N-ethyl-, lithium derivative; Lithium ethyl tosylamidate; Lithium ethyl p-toluenesulfonamidate; N-Ethyltosylamide lithium salt; Lithium N-ethyltosylamidate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Lithium n-Ethyl-p-Toluenesulphonamidate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including assay by titration and identification by FT-IR and NMR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Handle and open containers only in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Solubility Test	Soluble in THF, ethers; reacts with protic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.