Description

Eflornithine Hydrochloride is a potent and selective inhibitor of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for targeted therapeutic applications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for conditions involving uncontrolled cellular proliferation.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of hirsutism (excessive hair growth) in women.
• Oncology Research: Investigated in clinical and preclinical studies for its potential anti-proliferative effects against certain cancers, including glioblastoma and neuroblastoma.
• Parasitic Disease Treatment: Used in the formulation of drugs for late-stage African sleeping sickness (human African trypanosomiasis) caused by *Trypanosoma brucei gambiense*.
• Dermatological Formulations: Incorporated into topical creams and solutions for dermatological conditions related to rapid skin cell turnover.
• Biochemical Research: Serves as a essential tool compound in laboratories studying polyamine metabolism, enzyme inhibition, and cell cycle regulation.
• Reference Standard: Used as a high-purity certified reference material (CRM) in analytical laboratories for quality control and method development.

Basic Information

Product Name	Eflornithine Hydrochloride
CAS No.	68278-23-9
Molecular Formula	C6H12F2N2O2 • HCl
Molecular Weight	236.63 g/mol
Synonyms	DFMO Hydrochloride; 2-(Difluoromethyl)ornithine Hydrochloride; DL-α-Difluoromethylornithine Hydrochloride; Eflornithine HCl; Ornidyl; (RS)-2-(Difluoromethyl)ornithine Monohydrochloride; α-DFMO HCl; (±)-Eflornithine Hydrochloride
EINECS	Contact for details

Quality Control

Our Eflornithine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, impurity profile, and identification. We can supply material compliant with relevant pharmacopeial monographs upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range provided per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.