Description

Spdp CAS NO 68181-17-9 is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a sulfhydryl-reactive 2-pyridyldithiol group. This compound is essential for creating stable, cleavable conjugates between proteins, peptides, and other biomolecules, enabling advanced research and diagnostic applications. It is a critical tool for scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and protein labeling.

Application

• Bioconjugation and Protein Labeling: For creating covalent linkages between amines and thiols on proteins, antibodies, and enzymes for analytical or therapeutic purposes.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable linker to attach cytotoxic drugs to monoclonal antibodies, a key technology in targeted cancer therapies.
• Immobilization Chemistry: Used to functionalize surfaces (e.g., biosensor chips, chromatography resins) by coupling biomolecules via amine or sulfhydryl groups.
• Peptide Synthesis and Modification: Employed to introduce disulfide bonds or to conjugate peptides to carriers or labels.
• Diagnostic Assay Development: Facilitates the preparation of enzyme-antibody or hapten-protein conjugates used in ELISA and other immunoassays.
• Polymer and Biomaterial Science: Enables the crosslinking of polymers or modification of biomaterials to introduce specific biological functionalities.

Basic Information

Product Name	Spdp
CAS No.	68181-17-9
Molecular Formula	C₁₆H₂₀N₂O₆S₂
Molecular Weight	400.47 g/mol
Synonyms	N-Succinimidyl 3-(2-pyridyldithio)propionate; SPDP Crosslinker; 3-(2-Pyridyldithio)propionic Acid N-Hydroxysuccinimide Ester; Succinimidyl 3-(2-pyridyldithio)propionate; LC-SPDP; SMPT; N-Succinimidyl-3-(2-pyridyldithio)propionate
EINECS	Contact for details

Quality Control

Our Spdp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with lot-specific data are provided to guarantee reproducible performance and supply chain traceability.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.