Description

5-(Bromomethyl)-2,2-Difluorobenzo[D][1,3]Dioxole is a high-value, multi-functional aromatic building block featuring a reactive bromomethyl group and a stable difluorobenzodioxole moiety. This compound is critical for synthetic chemists requiring precise molecular modifications to develop advanced materials and active pharmaceutical ingredients. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used as a precursor in the development of next-generation herbicides and fungicides, leveraging the stability of the difluorobenzodioxole ring.
• Ligand & Catalyst Development: Serves as a versatile scaffold for constructing sophisticated ligands used in asymmetric catalysis and material science.
• Polymer & Material Science: Incorporated into specialty polymers and advanced organic electronic materials to impart specific electronic or physical properties.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent electrophile for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution and the benzodioxole group on chemical reactivity and biological activity.

Basic Information

Product Name	5-(Bromomethyl)-2,2-Difluorobenzo[D][1,3]Dioxole
CAS No.	68119-30-2
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	5-(Bromomethyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-5-(bromomethyl)-1,3-benzodioxole; 1,3-Benzodioxole, 5-(bromomethyl)-2,2-difluoro-; 68119-30-2; 5-Bromomethyl-2,2-difluorobenzo[d][1,3]dioxole
EINECS	Contact for details

Quality Control

Every batch of 5-(Bromomethyl)-2,2-Difluorobenzo[D][1,3]Dioxole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.