Description

2-Hydroxy Carbamazepine is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug carbamazepine. Its precise synthesis and high purity are critical for ensuring the safety and efficacy of final drug products and for conducting accurate pharmacokinetic studies. This compound is essential for manufacturers and research institutions in the pharmaceutical, analytical, and life science sectors focused on neurology and drug metabolism.

Application

• Pharmaceutical Intermediate: Primary building block in the synthesis of carbamazepine and its related derivatives.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in bioanalytical and quality control laboratories.
• Metabolite Studies: Critical for in-vitro and in-vivo drug metabolism and pharmacokinetic (DMPK) research to understand the metabolic pathway of carbamazepine.
• Impurity Standard: Serves as a known impurity standard for monitoring and controlling the quality of carbamazepine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Biochemical Research: Utilized in enzymatic and receptor-binding studies related to neurological pathways and drug mechanisms of action.

Basic Information

Product Name	2-Hydroxy Carbamazepine
CAS No.	68011-66-5
Molecular Formula	C15H12N2O2
Molecular Weight	252.27 g/mol
Synonyms	10,11-Dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide; 10-Hydroxy Carbamazepine; 10-OH-Carbamazepine; Carbamazepine-10,11-epoxide metabolite; Oxcarbazepine Related Compound; 5-Carbamoyl-10,11-dihydro-10-hydroxy-5H-dibenzo[b,f]azepine
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Carbamazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.