Description

Bis(2,4,6-Trimethylphenyl)Phosphine CAS NO 67950-05-4 is a sterically hindered tertiary phosphine ligand, prized for its role in facilitating challenging catalytic transformations. Its primary value lies in enhancing reaction rates and selectivity in cross-coupling and other organometallic processes, offering significant advantages in yield and purity for advanced chemical synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-performance ligands for metal-catalyzed reactions.

Application

• Ligand in Cross-Coupling Catalysis: A key component in palladium-catalyzed reactions such as Suzuki, Heck, and Negishi couplings for constructing complex organic molecules.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of active pharmaceutical ingredients (APIs) where precise bond formation is critical.
• Agrochemical Manufacturing: Employed in catalytic steps for the synthesis of advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a ligand in the preparation of novel organometallic complexes and catalysts for polymer and material development.
• Fine Chemical Production: Facilitates high-value, low-volume syntheses of flavors, fragrances, and electronic chemicals.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic and organometallic chemistry laboratories.

Basic Information

Product Name	Bis(2,4,6-Trimethylphenyl)Phosphine
CAS No.	67950-05-4
Molecular Formula	C24H27P
Molecular Weight	346.44 g/mol
Synonyms	Bis(mesityl)phosphine; Di(2,4,6-trimethylphenyl)phosphine; Tris(2,4,6-trimethylphenyl)phosphine (common misnomer, verify structure); P(Mes)2; Mes2PH (reduced form); 2,4,6-Trimethylphenylphosphine (ambiguous); Bis(2,4,6-trimethylphenyl)phosphane; Ligand SPhos (Note: SPhos is a related but different bidentate ligand; included for search relevance).
EINECS	Contact for details

Quality Control

Our Bis(2,4,6-Trimethylphenyl)Phosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent in-house specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, containers should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.